Andrew T Hattersley Selected Research

Hepatocyte Nuclear Factors

1/2020	Noninvasive Fetal Genotyping by Droplet Digital PCR to Identify Maternally Inherited Monogenic Diabetes Variants.
2/2015	HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum.
7/2012	Using highly sensitive C-reactive protein measurement to diagnose MODY in a family with suspected type 2 diabetes.
6/2008	Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.
7/2006	Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.
2/2006	Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.
7/2005	Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.
5/2004	Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.
5/2003	Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation.

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Andrew T Hattersley Research Topics

Disease

96	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2002
33	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 01/2003
29	Insulin Resistance 12/2021 - 01/2002
25	Hyperglycemia 01/2021 - 12/2002
20	Birth Weight (Birth Weights) 12/2021 - 01/2004
17	Mason-Type Diabetes 01/2021 - 01/2002
14	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 01/2003
11	Obesity 01/2021 - 04/2008
10	Diabetes Mellitus 01/2022 - 12/2002
9	Permanent Neonatal Diabetes Mellitus 01/2019 - 12/2004
7	Genetic Risk Score 01/2021 - 10/2013
6	Hyperinsulinism (Hyperinsulinemia) 01/2022 - 05/2004
4	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/2020 - 09/2007
4	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2020 - 10/2010
4	Cysts 02/2015 - 10/2001
3	Lipodystrophy 01/2022 - 01/2004
3	Disease Progression 01/2022 - 01/2018
3	Anemia 01/2021 - 10/2020
3	Kidney Diseases (Kidney Disease) 02/2015 - 12/2002
3	Hypothyroidism 12/2013 - 11/2009
3	Familial Partial Lipodystrophy (Dunnigan Syndrome) 03/2007 - 07/2003
3	Type 3 Maturity-Onset Diabetes of the Young 12/2003 - 11/2002
2	Chronic Renal Insufficiency 01/2022 - 12/2013
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 12/2005
2	Latent Autoimmune Diabetes in Adults 01/2021 - 06/2006
2	Dyslipidemias (Dyslipidemia) 01/2020 - 05/2004
2	Edema (Dropsy) 01/2020 - 01/2018
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020 - 01/2018
2	Overweight 12/2018 - 01/2009
2	Weight Gain 08/2018 - 01/2018
2	Exocrine Pancreatic Insufficiency 01/2016 - 03/2013
2	Microcephaly 11/2015 - 10/2013
2	Solitary Kidney 02/2015 - 04/2002
2	Deafness (Deaf Mutism) 06/2012 - 04/2008
2	Ketosis 08/2006 - 04/2004
2	Renal cysts and diabetes syndrome 11/2004 - 10/2001
2	Cystic Fibrosis (Mucoviscidosis) 01/2004 - 06/2003
2	Cystic Kidney Diseases (Cystic Kidney Disease) 12/2002 - 01/2002
1	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2021

Drug/Important Bio-Agent (IBA)

73	Insulin (Novolin)FDA Link 01/2022 - 01/2002
46	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2002
20	GlucokinaseIBA 01/2020 - 09/2003
19	C-PeptideIBA 01/2022 - 11/2008
16	AutoantibodiesIBA 01/2022 - 09/2007
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
12	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA 02/2011 - 01/2002
11	Biomarkers (Surrogate Marker)IBA 12/2021 - 12/2003
11	Transcription Factors (Transcription Factor)IBA 12/2015 - 01/2002
11	Hepatocyte Nuclear Factor 1-betaIBA 07/2009 - 10/2001
10	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 10/2003
9	Hepatocyte Nuclear FactorsIBA 01/2020 - 05/2003
9	Triglycerides (Triacylglycerol)IBA 01/2018 - 12/2005
8	P-2 (P 2)IBA 01/2020 - 06/2007
8	Adenosine Triphosphate (ATP)IBA 08/2012 - 11/2004
7	LipidsIBA 12/2021 - 01/2002
7	Biological ProductsIBA 12/2021 - 05/2003
6	CreatinineIBA 01/2020 - 02/2011
6	KATP ChannelsIBA 01/2019 - 02/2003
5	Pharmaceutical PreparationsIBA 01/2022 - 09/2003
5	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 01/2002
4	Glyburide (Glibenclamide)FDA LinkGeneric 01/2021 - 03/2005
4	ThiazolidinedionesIBA 10/2020 - 10/2003
4	ProinsulinIBA 01/2020 - 07/2005
4	Blood Glucose (Blood Sugar)IBA 11/2018 - 06/2005
3	EnzymesIBA 01/2021 - 06/2005
3	Hemoglobins (Hemoglobin)IBA 10/2020 - 11/2008
3	HDL CholesterolIBA 03/2016 - 12/2005
3	AdiponectinIBA 03/2016 - 01/2012
3	AntibodiesIBA 02/2014 - 07/2012
3	C-Reactive ProteinIBA 07/2012 - 12/2005
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2022 - 11/2018
2	Uric Acid (Urate)IBA 01/2022 - 05/2003
2	LeptinIBA 01/2022 - 10/2003
2	Glucagon (Glukagon)FDA Link 01/2021 - 11/2018
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 12/2020 - 01/2014
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2020 - 09/2015
2	Zinc Transporter 8IBA 01/2020 - 01/2019
2	AntigensIBA 01/2020 - 01/2019
2	IncretinsIBA 01/2019 - 01/2018
2	Vitamin D FDA LinkGeneric 01/2019 - 03/2016
2	Hormones (Hormone)IBA 11/2018 - 01/2012
2	Dihydrotachysterol (AT 10)IBA 01/2018 - 01/2009
2	Gonadal Steroid Hormones (Sex Hormones)IBA 10/2016 - 02/2010
2	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2016 - 12/2013
2	Glutamic Acid (Glutamate)FDA Link 02/2015 - 06/2011
2	Iodide Peroxidase (Deiodinase)IBA 02/2014 - 12/2013
2	cyclo(Arg-Pro) (CI 4)IBA 01/2014 - 12/2012
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 12/2012 - 08/2009
2	Thiamine (Aneurin)FDA Link 09/2012 - 06/2012
2	Lipoproteins (Lipoprotein)IBA 05/2012 - 01/2002
2	TabletsIBA 01/2012 - 09/2005
2	Hepatocyte Nuclear Factor 1IBA 08/2011 - 02/2011
2	Protein Isoforms (Isoforms)IBA 01/2010 - 08/2009
2	Lamin Type A (Lamin A)IBA 03/2007 - 07/2003

Therapy/Procedure

26	Therapeutics 01/2022 - 03/2005
5	Glycemic Control 01/2022 - 11/2003
4	Precision Medicine 08/2020 - 01/2017
3	Injections 01/2012 - 02/2008
2	Enzyme Replacement Therapy 08/2018 - 03/2013